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Increased intracellular Ca 2+ stimulates insulin secretion by closing ATP-sensitive K + -channels, depolarizing the cell membrane, and activating voltage-gated Ca 2+ -channels (132)

Its unique characteristics make it valuable for exploring biological rhythms, neuroendocrine interactions, and stress-adaptation pathways within controlled laboratory environments

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Went from daily episodes to maybe once or twice a month, and even then it is mild

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Both options include provider supervision, 503A compounded medication from a licensed pharmacy, dosing instructions, and follow-up